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Article

Stabilizing mutations increase secretion of functional soluble TCR-Ig fusion proteins.

BMC biotechnology - 24 Aug 2010

Lunde Elin, Løset Geir Åge, Bogen Bjarne, Sandlie Inger

Abstract excerpt

BACKGROUND: Whereas T cell receptors (TCRs) detect peptide/major histocompatibility complexes (pMHCs) with exquisite specificity, there are challenges regarding their expression and use as soluble detection molecules due to molecular instability. We have investigated strategies for the production of TCR-immunoglobulin (Ig) fusion proteins. Two different TCRs that are characteristic of a mouse model for idiotype...

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Identifiers

PMID: 20735812
DOI: 10.1186/1472-6750-10-61
PMCID: PMC2936418

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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