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Article

Mutations in yscC, yscD, and yscG prevent high-level expression and secretion of V antigen and Yops in Yersinia pestis.

Journal of bacteriology - 1 Jul 1995

Plano G V, Straley S C

Abstract excerpt

The Yersinia pestis low-Ca2+ response stimulon is responsible for the temperature- and Ca(2+)-regulated expression and secretion of plasmid pCD1-encoded antihost proteins (V antigen and Yops). We have previously shown that lcrD and yscR encode proteins that are essential for high-level expression and secretion of V antigen and Yops at 37 degrees C in the absence of Ca2+. In this study, we constructed and...

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Identifiers

PMID: 7601852
DOI: 10.1128/jb.177.13.3843-3854.1995
PMCID: PMC177105

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Source receipt: pubmed, retrieved 7 Sept 2026.

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Mutations in yscC, yscD, and yscG prevent high-level expression and secretion of V antigen and Yops in Yersinia pestis.PMID 7601852Read ↗

YscP of Yersinia pestis is a secreted component of the Yop secretion system.Semantic proximity Read ↗

YopD of Yersinia pestis plays a role in negative regulation of the low-calcium response in addition to its role in translocation of Yops.Semantic proximity Read ↗

Multiple effects of lcrD mutations in Yersinia pestis.Semantic proximity Read ↗

A complex composed of SycN and YscB functions as a specific chaperone for YopN in Yersinia pestis.Semantic proximity Read ↗

LcrG-LcrV interaction is required for control of Yops secretion in Yersinia pestis.Semantic proximity Read ↗

Autoproteolysis of YscU of Yersinia pseudotuberculosis is important for regulation of expression and secretion of Yop proteins.Semantic proximity Read ↗

YscB of Yersinia pestis functions as a specific chaperone for YopN.Semantic proximity Read ↗

The V antigen of Yersinia pestis regulates Yop vectorial targeting as well as Yop secretion through effects on YopB and LcrG.Semantic proximity Read ↗

Regulated secretion of YopN by the type III machinery of Yersinia enterocolitica.Semantic proximity Read ↗

The lcrB (yscN/U) gene cluster of Yersinia pseudotuberculosis is involved in Yop secretion and shows high homology to the spa gene clusters of Shigella flexneri and Salmonella typhimurium.Semantic proximity Read ↗

YscM1 and YscM2, two Yersinia enterocolitica proteins causing downregulation of yop transcription.Semantic proximity Read ↗

lcrR, a low-Ca2(+)-response locus with dual Ca2(+)-dependent functions in Yersinia pestis.Semantic proximity Read ↗

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