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Article

Expression and integrity of DNA topoisomerase II isoforms does not explain generic drug resistance in malignant mesothelioma.

Cancer chemotherapy and pharmacology - 1 Jul 2001

McLaren B R, Whitaker D, Robinson B W, Lake R A

Abstract excerpt

PURPOSE: Malignant mesothelioma is a tumour that is highly resistant to a number of different chemotherapy agents, yet the mechanisms by which resistance occurs are poorly understood. The pattern of resistance is consistent with disruption of topoisomerase function or expression. Coupled with this, we have previously noted a common serological reaction to the beta isoform of topoisomerase II, suggesting that it...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 11488518
DOI: 10.1007/s002800100281

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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