Article
Post-transcriptional regulation of ERBB2 by miR26a/b and HuR confers resistance to tamoxifen in estrogen receptor-positive breast cancer cells.
The Journal of biological chemistry - 18 Aug 2017
Tan Sheng, Ding Keshuo, Chong Qing-Yun, Zhao Junsong, Liu Yuan, Shao Yunying, Zhang Yuanyuan, Yu Qing, Xiong Zirui, Zhang Weijie, Zhang Min, Li Gaopeng, Li Xiaoni, Kong Xiangjun, Ahmad Akhlaq, Wu Zhengsheng, Wu Qiang, Zhao Xiaodong, Lobie Peter E, Zhu Tao
Abstract excerpt
Tamoxifen-resistant (TAMR) estrogen receptor-positive (ER+) breast cancer is characterized by elevated Erb-B2 receptor tyrosine kinase 2 (ERBB2) expression. However, the underlying mechanisms responsible for the increased ERBB2 expression in the TAMR cells remain poorly understood. Herein, we reported that the ERBB2 expression is regulated at the post-transcriptional level by miR26a/b and the RNA-binding protein...
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