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Article

Posttranscriptional regulation of the breast cancer susceptibility gene BRCA1 by the RNA binding protein HuR.

Cancer research - 15 Nov 2008

Saunus Jodi M, French Juliet D, Edwards Stacey L, Beveridge Dianne J, Hatchell Esme C, Wagner Sarah A, Stein Sandra R, Davidson Andrew, Simpson Kaylene J, Francis Glenn D, Leedman Peter J, Brown Melissa A

Abstract excerpt

BRCA1 is a breast cancer susceptibility gene that is down-regulated in a significant proportion of sporadic breast cancers. BRCA1 is posttranscriptionally regulated by RNA-binding proteins, the identities of which are unknown. HuR is an RNA binding protein implicated in posttranscriptional regula...

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Source

Identifiers

PMID: 19010922
DOI: 10.1158/0008-5472.CAN-08-1159

Genes

BRCA1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19010922-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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Posttranscriptional regulation of the breast cancer susceptibility gene BRCA1 by the RNA binding protein HuR.PMID 19010922Read ↗

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HuR Reduces Radiation-Induced DNA Damage by Enhancing Expression of ARID1ASemantic proximity Read ↗

Embryonic Lethal Abnormal Vision-like HuR-dependent mRNA Stability Regulates Post-transcriptional Expression of Cyclin-dependent Kinase Inhibitor p27Kip1Semantic proximity Read ↗

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HuR binds to flanking exons and regulates intron retention alternative splicing of cell cycle-related genes in smooth muscle cellsSemantic proximity Read ↗

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Clinical Significance and Biological Role of HuR in Head and Neck CarcinomasSemantic proximity Read ↗

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