Article
ING1a expression increases during replicative senescence and induces a senescent phenotype.
Aging cell - 1 Dec 2008
Soliman Mohamed A, Berardi Philip, Pastyryeva Svitlana, Bonnefin Paul, Feng Xiaolan, Colina Ana, Young Dallan, Riabowol Karl
Abstract excerpt
The ING family of tumor suppressor proteins affects cell growth, apoptosis and response to DNA damage by modulating chromatin structure through association with different HAT and HDAC complexes. The major splicing isoforms of the ING1 locus are ING1a and INGlb. While INGlb plays a role in inducing apoptosis, the function of ING1a is currently unknown. Here we show that alternative splicing of the ING1 message...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.