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Article

B Cell–Intrinsic Expression of the HuR RNA-Binding Protein Is Required for the T Cell–Dependent Immune Response In Vivo

29 Aug 2015

Abstract excerpt

The HuR RNA-binding protein posttranscriptionally controls expression of genes involved in cellular survival, proliferation, and differentiation. To determine roles of HuR in B cell development and function, we analyzed mice with B lineage-specific deletion of the HuR gene. These HuRΔ/Δ mice have reduced numbers of immature bone marrow and mature splenic B cells, with only the former rescued by p53 inactivation,...

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PMID: 26320247
DOI: 10.4049/jimmunol.1500512

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B Cell–Intrinsic Expression of the HuR RNA-Binding Protein Is Required for the T Cell–Dependent Immune Response In VivoPMID 26320247Read ↗

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