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Article

HuR protein attenuates miRNA-mediated repression by promoting miRISC dissociation from the target RNA.

Nucleic acids research - 1 Jun 2012

Kundu Pradipta, Fabian Marc R, Sonenberg Nahum, Bhattacharyya Suvendra N, Filipowicz Witold

Abstract excerpt

The microRNA (miRNA)-mediated repression of protein synthesis in mammalian cells is a reversible process. Target mRNAs with regulatory AU-rich elements (AREs) in their 3'-untranslated regions (3'-UTR) can be relieved of miRNA repression under cellular stress in a process involving the embryonic lethal and altered vision family ARE-binding protein HuR. The HuR-mediated derepression occurred even when AREs were...

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PMID: 22362743
DOI: 10.1093/nar/gks148
PMCID: PMC3367187

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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