Article
Influence of maternal and fetal glucokinase mutations in gestational diabetes.
American journal of obstetrics and gynecology - 1 Jul 2001
Spyer G, Hattersley A T, Sykes J E, Sturley R H, MacLeod K M
Abstract excerpt
We report 2 insulin-treated pregnancies in a mother with hyperglycemia resulting from a glucokinase gene mutation. The inheritance of a glucokinase mutation in 1 child reduced his intrauterine growth (birth weight less than first percentile) by reducing fetal insulin secretion. We discuss the implications for obstetric management of patients with glucokinase mutations.
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