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Article

The long-term impact on offspring of exposure to hyperglycaemia in utero due to maternal glucokinase gene mutations.

Diabetologia - 1 Mar 2007

Singh R, Pearson E R, Clark P M, Hattersley A T

Abstract excerpt

AIMS/HYPOTHESIS: There is strong evidence that maternal diabetes while offspring are in utero results in offspring beta cell dysfunction and diabetes or glucose intolerance. Offspring born to mothers with a mutation in the glucokinase gene (GCK) are a good model for studying exposure to moderate...

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Source

Identifiers

PMID: 17216282
DOI: 10.1007/s00125-006-0541-8

Genes

GCK

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17216282-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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The long-term impact on offspring of exposure to hyperglycaemia in utero due to maternal glucokinase gene mutations.PMID 17216282Read ↗

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Intrauterine diabetic environment confers risks for type 2 diabetes mellitus and obesity in the offspring, in addition to genetic susceptibility.Semantic proximity Read ↗

Long-term effects on offspring of intrauterine exposure to deficits in nutritionSemantic proximity Read ↗

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Antenatal diagnosis of fetal genotype determines if maternal hyperglycemia due to a glucokinase mutation requires treatment.Semantic proximity Read ↗

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