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Article

Antenatal diagnosis of fetal genotype determines if maternal hyperglycemia due to a glucokinase mutation requires treatment.

Diabetes care - 1 Sept 2012

Chakera Ali J, Carleton Victoria L, Ellard Sian, Wong Jencia, Yue Dennis K, Pinner Jason, Hattersley Andrew T, Ross Glynis P

Abstract excerpt

OBJECTIVE: In women with hyperglycemia due to heterozygous glucokinase (GCK) mutations, the fetal genotype determines its growth. If the fetus inherits the mutation, birth weight is normal when maternal hyperglycemia is not treated, whereas intensive treatment may adversely reduce fetal growth. However, fetal genotype is not usually known antenatally, making treatment decisions difficult. HISTORY AND EXAMINATION:...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 22773699
DOI: 10.2337/dc12-0151
PMCID: PMC3425005

Genes

GCK

Provenance

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Antenatal diagnosis of fetal genotype determines if maternal hyperglycemia due to a glucokinase mutation requires treatment.PMID 22773699Read ↗

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