Pregnancy in Women With Monogenic Diabetes due to Pathogenic Variants of the Glucokinase Gene: Lessons and Challenges.

doi:10.3389/fendo.2021.802423

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Article

Pregnancy in Women With Monogenic Diabetes due to Pathogenic Variants of the Glucokinase Gene: Lessons and Challenges.

Frontiers in endocrinology - 1 Jan 2021

Timsit José, Ciangura Cécile, Dubois-Laforgue Danièle, Saint-Martin Cécile, Bellanne-Chantelot Christine

Abstract excerpt

Heterozygous loss-of-function variants of the glucokinase (GCK) gene are responsible for a subtype of maturity-onset diabetes of the young (MODY). GCK-MODY is characterized by a mild hyperglycemia, mainly due to a higher blood glucose threshold for insulin secretion, and an up-regulated glucose counterregulation. GCK-MODY patients are asymptomatic, are not exposed to diabetes long-term complications, and do not...

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PMID: 35069449
DOI: 10.3389/fendo.2021.802423
PMCID: PMC8766338

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