Article
Comparative characteristics of mu chain and alpha chain transcripts expressed by individual tonsil plasma cells.
Molecular immunology - 1 Jan 2001
Yavuz S, Grammer A C, Yavuz A S, Nanki T, Lipsky P E
Abstract excerpt
Plasma cells (PCs) are one of the two major cell types generated during germinal center reactions. To test the hypothesis that PCs express a unique repertoire of immunoglobulin (Ig) genes resulting from intensive antigenic stimulation and selection, the mutational pattern and distribution of V(H) gene segments within 178 transcripts amplified from individual IgM and IgA secreting tonsil PCs were analyzed. The...
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