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Article

A role of PDGFRalpha in basal cell carcinoma proliferation.

Proceedings of the National Academy of Sciences of the United States of America - 31 Jul 2001

Xie J, Aszterbaum M, Zhang X, Bonifas J M, Zachary C, Epstein E, McCormick F

Abstract excerpt

Activation of the hedgehog pathway, through the loss of patched (PTC) or the activation of smoothened (SMO), occurs frequently in basal cell carcinoma (BCC), the most common human cancer. However, the molecular basis of this neoplastic effect is not understood. The downstream molecule Gli1 is known to mediate the biological effect of the pathway and is itself up-regulated in all BCCs. Gli1 can drive the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 11481486
DOI: 10.1073/pnas.151173398
PMCID: PMC55407

Genes

SMO

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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