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Article

Escherichia coli SecA helicase activity is not required in vivo for efficient protein translocation or autogenous regulation.

The Journal of biological chemistry - 5 Oct 2001

Schmidt M O, Brosh R M, Oliver D B

Abstract excerpt

SecA is an essential ATP-driven motor protein that binds to preproteins and the translocon to promote protein translocation across the eubacterial plasma membrane. Escherichia coli SecA contains seven conserved motifs characteristic of superfamily II of DNA and RNA helicases, and it has been shown previously to possess RNA helicase activity. SecA has also been shown to be an autogenous repressor that binds to its...

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Identifiers

PMID: 11477104
DOI: 10.1074/jbc.M104584200

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

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Research trail→

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Escherichia coli SecA helicase activity is not required in vivo for efficient protein translocation or autogenous regulation.PMID 11477104Read ↗

Identification of the preprotein binding domain of SecA.Semantic proximity Read ↗

Isolation and analysis of dominant secA mutations in Escherichia coli.Semantic proximity Read ↗

Escherichia coli SecA truncated at its termini is functional and dimeric.Semantic proximity Read ↗

Dimeric SecA is essential for protein translocation.Semantic proximity Read ↗

Dynamic action of the Sec machinery during initiation, protein translocation and termination.Semantic proximity Read ↗

Critical regions of secM that control its translation and secretion and promote secretion-specific secA regulation.Semantic proximity Read ↗

A large conformational change couples the ATP binding site of SecA to the SecY protein channel.Semantic proximity Read ↗

SecA protein: autoregulated initiator of secretory precursor protein translocation across the E. coli plasma membrane.Semantic proximity Read ↗

Roles of SecG in ATP- and SecA-dependent protein translocation.Semantic proximity Read ↗

SecY and SecA interact to allow SecA insertion and protein translocation across the Escherichia coli plasma membrane.Semantic proximity Read ↗

Quaternary dynamics of the SecA motor drive translocase catalysis.Semantic proximity Read ↗

Two alternative binding mechanisms connect the protein translocation Sec71-Sec72 complex with heat shock proteins.Semantic proximity Read ↗

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