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Article

Identification of the preprotein binding domain of SecA.

The Journal of biological chemistry - 30 Dec 2005

Papanikou Efrosyni, Karamanou Spyridoula, Baud Catherine, Frank Miriam, Sianidis Giorgos, Keramisanou Dimitra, Kalodimos Charalampos G, Kuhn Andreas, Economou Anastassios

Abstract excerpt

SecA, the preprotein translocase ATPase, has a helicase DEAD motor. To catalyze protein translocation, SecA possesses two additional flexible domains absent from other helicases. Here we demonstrate that one of these "specificity domains" is a preprotein binding domain (PBD). PBD is essential for viability and protein translocation. PBD mutations do not abrogate the basal enzymatic properties of SecA (nucleotide...

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Identifiers

PMID: 16243836
DOI: 10.1074/jbc.M509990200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Identification of the preprotein binding domain of SecA.PMID 16243836Read ↗

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