Article
A polymorphism in human TLR2 is associated with increased susceptibility to tuberculous meningitis.
Genes and immunity - 1 Jul 2007
Thuong N T T, Hawn T R, Thwaites G E, Chau T T H, Lan N T N, Quy H T, Hieu N T, Aderem A, Hien T T, Farrar J J, Dunstan S J
Abstract excerpt
Tuberculous meningitis (TBM) results from the haematogenous dissemination of Mycobacterium tuberculosis from the lung to the brain. Dissemination is believed to occur early during infection, before the development of adaptive immunity. Toll-like receptor 2 (TLR2) mediates recognition of M. tuberculosis and initiates the innate immune response to infection. We hypothesized that polymorphisms in the TLR2 gene...
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