Article
HLA class I and II in Lambert-Eaton myasthenic syndrome without associated tumor.
Human immunology - 1 Aug 2001
Wirtz P W, Roep B O, Schreuder G M, van Doorn P A, van Engelen B G, Kuks J B, Twijnstra A, de Visser M, Visser L H, Wokke J H, Wintzen A R, Verschuuren J J
Abstract excerpt
Lambert-Eaton myasthenic syndrome (LEMS) is an autoimmune disorder, in which antibodies against voltage-gated calcium channels located at nerve terminals cause muscle weakness and autonomic dysfunction. In approximately half of the patients the autoimmune process is initiated by a tumor. In the other half of patients no tumor is found and the etiology is unknown. The aims of this study were to investigate the...
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