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Article

Late-onset myasthenia gravis - CTLA4(low) genotype association and low-for-age thymic output of naïve T cells.

Journal of autoimmunity - 1 Aug 2014

Chuang Wen-Yu, Ströbel Philipp, Bohlender-Willke Anna-Lena, Rieckmann Peter, Nix Wilfred, Schalke Berthold, Gold Ralf, Opitz Andreas, Klinker Erdwine, Inoue Masayoshi, Müller-Hermelink Hans Konrad, Saruhan-Direskeneli Güher, Bugert Peter, Willcox Nick, Marx Alexander

Abstract excerpt

Late-onset myasthenia gravis (LOMG) has become the largest MG subgroup, but the underlying pathogenetic mechanisms remain mysterious. Among the few etiological clues are the almost unique serologic parallels between LOMG and thymoma-associated MG (TAMG), notably autoantibodies against acetylcholine receptors, titin, ryanodine receptor, type I interferons or IL-12. This is why we checked LOMG patients for two...

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Identifiers

PMID: 24373506
DOI: 10.1016/j.jaut.2013.12.006

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CTLA4
AIRE

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