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Article

Solution structure of the third immunoglobulin domain of the neural cell adhesion molecule N-CAM: can solution studies define the mechanism of homophilic binding?

Journal of molecular biology - 3 Aug 2001

Atkins A R, Chung J, Deechongkit S, Little E B, Edelman G M, Wright P E, Cunningham B A, Dyson H J

Abstract excerpt

Homophilic binding of the neural cell adhesion molecule (N-CAM) mediates the calcium-independent cell-cell adhesion that is involved in neuronal development. Two hypotheses have been advanced for the mechanism of homophilic binding. Cell-based experiments have implicated each of the five extracellular immunoglobulin (Ig) domains of N-CAM in the homophilic adhesion interaction, and have predicted that the third...

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Identifiers

PMID: 11469865
DOI: 10.1006/jmbi.2001.4861

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Solution structure of the third immunoglobulin domain of the neural cell adhesion molecule N-CAM: can solution studies define the mechanism of homophilic binding?PMID 11469865Read ↗

Identification of a peptide sequence involved in homophilic binding in the neural cell adhesion molecule NCAM.Semantic proximity Read ↗

Structure and function of C-CAM1. The first immunoglobulin domain is required for intercellular adhesion.Semantic proximity Read ↗

Homophilic intercellular adhesion mediated by C-CAM is due to a domain 1-domain 1 reciprocal binding.Semantic proximity Read ↗

Sequential binding of calcium leads to dimerization in neural cadherin.Semantic proximity Read ↗

Disruption of the GDNF binding site in NCAM dissociates ligand binding and homophilic cell adhesion.Semantic proximity Read ↗

Binding of neural cell adhesion molecules (N-CAMs) to the cellular prion protein.Semantic proximity Read ↗

Mechanisms of self-association of a human monoclonal antibody CNTO607.Semantic proximity Read ↗

Identification of a homophilic binding site in immunoglobulin-like domain 2 of the cell adhesion molecule L1.Semantic proximity Read ↗

Expression and function of calcium binding domain chimeras of the integrins alpha(IIb) and alpha(5).Semantic proximity Read ↗

Single molecule adhesion measurements reveal two homophilic neural cell adhesion molecule bonds with mechanically distinct properties.Semantic proximity Read ↗

Calmodulin binds to specific sequences in the cytoplasmic domain of C-CAM and down-regulates C-CAM self-association.Semantic proximity Read ↗

Structural requirements for neural cell adhesion molecule-heparin interaction.Semantic proximity Read ↗

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