Article
Calmodulin binds to specific sequences in the cytoplasmic domain of C-CAM and down-regulates C-CAM self-association.
The Journal of biological chemistry - 19 Jan 1996
Edlund M, Blikstad I, Obrink B
Abstract excerpt
C-CAM is a cell adhesion molecule belonging to the immunoglobulin supergene family and is known to mediate calcium-independent homophilic cell-cell binding. Two major isoforms, C-CAM1 and C-CAM2, which differ in their cytoplasmic domains, have been identified. Previous investigations have demonst...
Topics
- Adenosine Triphosphatases
- Amino Acid Sequence
- Animals
- Antigens, CD
- Binding Sites
- Calmodulin
- Carcinoembryonic Antigen
- Cell Adhesion
- Cell Adhesion Molecules
- Cytoplasm
- Genetic Variation
- Glycoproteins
- Humans
- Kinetics
- Macromolecular Substances
- Mice
- Molecular Sequence Data
- Peptide Fragments