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Article

Transformation of the germ line into muscle in mes-1 mutant embryos of C. elegans.

Development (Cambridge, England) - 1 Sept 1995

Strome S, Martin P, Schierenberg E, Paulsen J

Abstract excerpt

Mutations in the maternal-effect sterile gene mes-1 cause the offspring of homozygous mutant mothers to develop into sterile adults. Lineage analysis revealed that mutant offspring are sterile because they fail to form primordial germ cells during embryogenesis. In wild-type embryos, the primordial germ cell P4 is generated via a series of four unequal stem-cell divisions of the zygote. mes-1 embryos display a...

Topics

Animals
Caenorhabditis elegans
Cell Differentiation
Cell Division
Cell Polarity
Female
Genes, Helminth
Germ Cells
Infertility, Female
Models, Biological
Morphogenesis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Muscles

Mutation

Source

Identifiers

PMID: 7555722
DOI: 10.1242/dev.121.9.2961

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7555722-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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