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Article

SynMuv genes redundantly inhibit lin-3/EGF expression to prevent inappropriate vulval induction in C. elegans.

Developmental cell - 1 May 2006

Cui Mingxue, Chen Jun, Myers Toshia R, Hwang Byung Joon, Sternberg Paul W, Greenwald Iva, Han Min

Abstract excerpt

Activation of EGFR-Ras-MAPK signaling in vulval precursor cells (VPCs) by LIN-3/EGF from the gonad induces vulval development in C. elegans. The prevailing view is that LIN-3 overcomes an "inhibitory signal" from the adjacent hyp7 hypodermal syncytium. This view originated from observations indicating that inactivation of functionally redundant Synthetic Multivulva (SynMuv) genes in hyp7 can activate...

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Identifiers

PMID: 16678779
DOI: 10.1016/j.devcel.2006.04.001

Genes

EGF
EGFR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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SynMuv genes redundantly inhibit lin-3/EGF expression to prevent inappropriate vulval induction in C. elegans.PMID 16678779Read ↗

The Caenorhabditis elegans synthetic multivulva genes prevent ras pathway activation by tightly repressing global ectopic expression of lin-3 EGF.Semantic proximity Read ↗

Diverse chromatin remodeling genes antagonize the Rb-involved SynMuv pathways in C. elegans.Semantic proximity Read ↗

HPL-2/HP1 prevents inappropriate vulval induction in Caenorhabditis elegans by acting in both HYP7 and vulval precursor cells.Semantic proximity Read ↗

dpl-1 DP and efl-1 E2F act with lin-35 Rb to antagonize Ras signaling in C. elegans vulval development.Semantic proximity Read ↗

SUMV-1 antagonizes the activity of synthetic multivulva genes in Caenorhabditis elegans.Semantic proximity Read ↗

Identification and classification of genes that act antagonistically to let-60 Ras signaling in Caenorhabditis elegans vulval development.Semantic proximity Read ↗

Caenorhabditis elegans lin-13, a member of the LIN-35 Rb class of genes involved in vulval development, encodes a protein with zinc fingers and an LXCXE motif.Semantic proximity Read ↗

Some C. elegans class B synthetic multivulva proteins encode a conserved LIN-35 Rb-containing complex distinct from a NuRD-like complex.Semantic proximity Read ↗

C. elegans ISWI and NURF301 antagonize an Rb-like pathway in the determination of multiple cell fates.Semantic proximity Read ↗

gon-14 functions with class B and class C synthetic multivulva genes to control larval growth in Caenorhabditis elegans.Semantic proximity Read ↗

Multiple levels of redundant processes inhibit Caenorhabditis elegans vulval cell fates.Semantic proximity Read ↗

A new class of C. elegans synMuv genes implicates a Tip60/NuA4-like HAT complex as a negative regulator of Ras signaling.Semantic proximity Read ↗

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