Quantification of unintegrated HIV-1 DNA at the single cell level in vivo.

Abstract excerpt

In the nucleus of HIV-1 infected cells, unintegrated HIV-1 DNA molecules exist in the form of one and two LTR circles and linear molecules with degraded extremities. In tissue culture they are invariably more numerous than the provirus, the relative proportion of integrated to unintegrated forms varies widely from ∼1:1 to 1:10 and even over 1:100. In vivo, this ratio is unknown. To determine it, single nuclei...

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• Share to Cell Nucleus
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• Share to env Gene Products, Human Immunodeficiency Virus