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Article

The LEP gene and age of menarche: maternal age as a potential cause of hidden stratification in association studies.

Molecular genetics and metabolism - 1 Jul 2001

Comings D E, Gade R, Muhleman D, Peters W R, MacMurray J P

Abstract excerpt

Leptin has a powerful effect on fertility and the initiation of puberty in addition to its effect on obesity. It has been suggested that that in times of fasting, infertility induced by low leptin levels protect the female from the energy demands of pregnancy. Despite this there have been no studies of the potential role of LEP gene variants on the age of onset of menarche. We genotyped 183 non-Hispanic Caucasian...

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Source

Identifiers

PMID: 11461187
DOI: 10.1006/mgme.2001.3192

Genes

LEP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 9 closest

The LEP gene and age of menarche: maternal age as a potential cause of hidden stratification in association studies.PMID 11461187Read ↗

The LEP G-2548A gene polymorphism is associated with age at menarche and breast cancer susceptibility.Semantic proximity Read ↗

Association of the Q223R polymorphism with age at menarche in the leptin receptor gene in humans.Semantic proximity Read ↗

Three common variants of LEP, NPY1R and GPR54 show no association with age at menarche.Semantic proximity Read ↗

Genetics of age at menarche: a systematic review.Semantic proximity Read ↗

Polymorphisms in adiposity-related genes are associated with age at menarche and menopause in breast cancer patients and healthy women.Semantic proximity Read ↗

Polymorphism in the insulin-like growth factor 1 gene is associated with age at menarche in caucasian females.Semantic proximity Read ↗

Comparison between two analytic strategies to detect linkage to obesity with genetically determined age of onset: the Framingham Heart Study.Semantic proximity Read ↗

Age at menarche and menopause is not associated with two common genetic variants in the methylenetetrahydrofolate reductase (MTHFR) gene.Semantic proximity Read ↗

The chemokine (C-C-motif) receptor 3 (CCR3) gene is linked and associated with age at menarche in Caucasian females.Semantic proximity Read ↗

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