Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The LEP G-2548A gene polymorphism is associated with age at menarche and breast cancer susceptibility.

Gene - 25 Feb 2015

Rostami Sara, Kohan Leila, Mohammadianpanah Mohammad

Abstract excerpt

Leptin is an adipocytokine made by fat cells and plays a key role in proliferation, cell survival, migration and immune response. It has a powerful effect on the initiation of puberty and in determining age at menarche. The current study is the first investigation to examine the effect of G-2548A leptin gene polymorphism on the age at menarche and breast cancer susceptibility. This case-control study was...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adolescent
Share to Breast Neoplasms
Share to Case-Control Studies

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Frequency

Share to Leptin

Share to Menarche

Share to Polymorphism, Single Nucleotide

Source

Identifiers

PMID: 25510398
DOI: 10.1016/j.gene.2014.12.021

Genes

LEP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The LEP G-2548A gene polymorphism is associated with age at menarche and breast cancer susceptibility.PMID 25510398Read ↗

Polymorphisms in adiposity-related genes are associated with age at menarche and menopause in breast cancer patients and healthy women.Semantic proximity Read ↗

Association of the Q223R polymorphism with age at menarche in the leptin receptor gene in humans.Semantic proximity Read ↗

Association Between Leptin (-2548G/A) Genes Polymorphism and Breast Cancer Susceptibility: A Meta-Analysis.Semantic proximity Read ↗

Influence of the leptin G-2548A polymorphism on leptin levels and anthropometric measurements in healthy Spanish adolescents.Semantic proximity Read ↗

Polymorphisms in three obesity-related genes (LEP, LEPR, and PON1) and breast cancer risk: a meta-analysis.Semantic proximity Read ↗

Role of leptin G-2548A polymorphism in age- and gender-specific development of obesity.Semantic proximity Read ↗

Genetic G2548A polymorphism of leptin gene and risk of cancer: a meta-analysis of 6860 cases and 7956 controls.Semantic proximity Read ↗

Leptin--2548 g/A polymorphism in endometrial cancer.Semantic proximity Read ↗

LEP (-2548G>A LEP) and LEPR (223Gln>Arg, 109Lys>Arg) polymorphisms as breast cancer risk factors in the Polish female population.Semantic proximity Read ↗

Leptin G-2548A promoter polymorphism is associated with increased plasma leptin and BMI in Brazilian women.Semantic proximity Read ↗

Association with leptin gene C.-2548 G>A polymorphism, serum leptin levels, and body mass index in Turkish obese patients.Semantic proximity Read ↗

Overexpressing leptin genetic polymorphism (-2548 G/A) is associated with susceptibility to prostate cancer and risk of advanced disease.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.