Article
Age-dependent effects of secreted Semaphorins 3A, 3F, and 3E on developing hippocampal axons: in vitro effects and phenotype of Semaphorin 3A (-/-) mice.
Molecular and cellular neurosciences - 1 Jul 2001
Pozas E, Pascual M, Nguyen Ba-Charvet K T, Guijarro P, Sotelo C, Chédotal A, Del Río J A, Soriano E
Abstract excerpt
We studied the role of Semaphorins in the formation of hippocampal connections at embryonic and early postnatal stages. We show that the embryonic entorhinal cortex has a repulsive effect on embryonic hippocampal axons that disappears gradually at postnatal stages. Such chemorepulsion is blocked by Neuropilin-1 and -2 blocking antibodies. However, at perinatal stages, the inner layers of the entorhinal cortex...
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