Article
Stereotyped pruning of long hippocampal axon branches triggered by retraction inducers of the semaphorin family.
Cell - 2 May 2003
Bagri Anil, Cheng Hwai-Jong, Yaron Avraham, Pleasure Samuel J, Tessier-Lavigne Marc
Abstract excerpt
Like naturally occurring neuronal cell death, stereotyped pruning of long axon branches to temporary targets is a widespread regressive phenomenon in the developing mammalian brain that helps sculpt the pattern of neuronal connections. The mechanisms controlling stereotyped pruning are, however, poorly understood. Here, we provide evidence that semaphorins, activating the Plexin-A3 receptor, function as...
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