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Article

Critical role for transcription factor AP-2α in human trophoblast differentiation

30 Mar 2004

Abstract excerpt

To examine whether AP-2alpha is a critical component of the genetic program that directs human trophoblast differentiation, we used DNA microarray analyses to characterize the effects of a dominant-negative form of the AP-2 protein upon in vitro differentiating cytotrophoblast cells. Human cytotrophoblast cells (>95% pure) were cultured for 3 days in the presence of control medium or medium containing an...

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PMID: 15039486
DOI: 10.1152/physiolgenomics.00181.2003

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