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Article

Id-2 regulates critical aspects of human cytotrophoblast differentiation, invasion and migration

1 Feb 2000

Abstract excerpt

During early human placental development, the conceptus attaches itself to the uterus through cytotrophoblast invasion. Invasive cytotrophoblast cells differentiate from precursor villous cytotrophoblasts, but the essential regulating factors in this process are unknown. Basic helix-loop-helix (bHLH) transcription factor dimers are essential regulators of mouse trophoblast development. We therefore examined the...

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PMID: 10631176
DOI: 10.1242/dev.127.3.549

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