Article
Heterogeneity of tumor endothelial cells: comparison between tumor endothelial cells isolated from high- and low-metastatic tumors.
The American journal of pathology - 1 Mar 2012
Ohga Noritaka, Ishikawa Shuhei, Maishi Nako, Akiyama Kosuke, Hida Yasuhiro, Kawamoto Taisuke, Sadamoto Yoshihiro, Osawa Takahiro, Yamamoto Kazuyuki, Kondoh Miyako, Ohmura Hitomi, Shinohara Nobuo, Nonomura Katsuya, Shindoh Masanobu, Hida Kyoko
Abstract excerpt
An important concept in tumor angiogenesis is that tumor endothelial cells (TECs) are genetically normal and homogeneous. However, we previously reported that TECs differ from normal ECs. Whether the characteristics of TECs derived from different tumors differ remains unknown. To elucidate this, in this study, we isolated two types of TECs from high-metastatic (HM) and low-metastatic (LM) tumors and compared...
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