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Article

Synthesis and evaluation of novel quinolinones as HIV-1 reverse transcriptase inhibitors.

Bioorganic & medicinal chemistry letters - 23 Jul 2001

Patel M, McHugh R J, Cordova B C, Klabe R M, Bacheler L T, Erickson-Viitanen S, Rodgers J D

Abstract excerpt

A series of 4,4-disubstituted quinolinones was prepared and evaluated as HIV-1 reverse transcriptase inhibitors. The C-3 substituted compound 9h displayed improved antiviral activity against clinically significant single (K103N) and double (K103N/L100I) mutant viruses.

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Identifiers

PMID: 11459666
DOI: 10.1016/s0960-894x(01)00331-6

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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