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Discovery of 2,4,5-Trisubstituted 6-Aminopyrimidines as Potent HIV-1 NNRTIs with Improved Resistance Profiles against the K103N/Y181C Mutant

2026-08-24

Abstract excerpt

<b>Background and Purpose:</b> The emergence of drug-resistant HIV-1 variants, particularly the clinically challenging K103N/Y181C double mutant, compromises the efficacy of current non-nucleoside reverse transcriptase inhibitors (NNRTIs). This study aimed to develop novel NNRTIs with potent antiviral activity and improved activity against clinically relevant resistant HIV-1 variants. <b>Experimental Approach:</b>...

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Literature Corpus work: 59601c1a-952a-5f21-b17b-ae195ee32637
DOI: 10.22541/authorea.15007782/v1

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