Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Quinolinonyl Non-Diketo Acid Derivatives as Inhibitors of HIV-1 Ribonuclease H and Polymerase Functions of Reverse Transcriptase.

Journal of medicinal chemistry - 24 Jun 2021

Messore Antonella, Corona Angela, Madia Valentina Noemi, Saccoliti Francesco, Tudino Valeria, De Leo Alessandro, Ialongo Davide, Scipione Luigi, De Vita Daniela, Amendola Giorgio, Novellino Ettore, Cosconati Sandro, Métifiot Mathieu, Andreola Marie-Line, Esposito Francesca, Grandi Nicole, Tramontano Enzo, Costi Roberta, Di Santo Roberto

Abstract excerpt

Novel anti-HIV agents are still needed to overcome resistance issues, in particular inhibitors acting against novel viral targets. The ribonuclease H (RNase H) function of the reverse transcriptase (RT) represents a validated and promising target, and no inhibitor has reached the clinical pipeline yet. Here, we present rationally designed non-diketo acid selective RNase H inhibitors (RHIs) based on the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Anti-HIV Agents
Share to HeLa Cells

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Magnesium

Share to Molecular Docking Simulation

Share to Mutagenesis, Site-Directed

Share to Quinolones

Share to Reverse Transcriptase Inhibitors

Share to Virus Replication

Source

Open in PubMed Open full text

Identifiers

PMID: 34106711
DOI: 10.1021/acs.jmedchem.1c00535
PMCID: PMC8279492

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Quinolinonyl Non-Diketo Acid Derivatives as Inhibitors of HIV-1 Ribonuclease H and Polymerase Functions of Reverse Transcriptase.PMID 34106711Read ↗

<i>N</i>-Substituted Quinolinonyl Diketo Acid Derivatives as HIV Integrase Strand Transfer Inhibitors and Their Activity against RNase H Function of Reverse TranscriptaseSemantic proximity Read ↗

HIV-1 RT-Associated RNase H Function Inhibitors: Recent Advances in Drug DevelopmentSemantic proximity Read ↗

Prediction of the binding mode and resistance profile for a dual-target pyrrolyl diketo acid scaffold against HIV-1 integrase and reverse-transcriptase-associated ribonuclease H.Semantic proximity Read ↗

Investigation of a novel series of 2-hydroxyisoquinoline-1,3(2H,4H)-diones as human immunodeficiency virus type 1 integrase inhibitors.Semantic proximity Read ↗

3-Hydroxypyrimidine-2,4-diones as an inhibitor scaffold of HIV integrase.Semantic proximity Read ↗

Targeting the retroviral ribonuclease H by rational drug design.Semantic proximity Read ↗

Unveiling the antiviral capabilities of targeting Human Dihydroorotate Dehydrogenase against SARS-CoV-2Semantic proximity Read ↗

Non-peptidic HIV protease inhibitors.Semantic proximity Read ↗

Identification and biological evaluation of a series of 1H-benzo[de]isoquinoline-1,3(2H)-diones as hepatitis C virus NS5B polymerase inhibitors.Semantic proximity Read ↗

Development of enhanced HIV-1 non-nucleoside reverse transcriptase inhibitors with improved resistance and pharmacokinetic profiles.Semantic proximity Read ↗

Synthesis and biological activity of heteroaryl 3-(1,1-dioxo-2H-(1,2,4)-benzothiadizin-3-yl)-4-hydroxy-2(1H)-quinolinone derivatives as hepatitis C virus NS5B polymerase inhibitors.Semantic proximity Read ↗

Exploiting drug-resistant enzymes as tools to identify thienopyrimidinone inhibitors of human immunodeficiency virus reverse transcriptase-associated ribonuclease H.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.