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Article

Smad2 overexpression induces alveolar bone loss and up regulates TNF-α, and RANKL.

Archives of oral biology - 1 Nov 2016

Alotaibi Mazen K, Kitase Yukiko, Shuler Charles F

Abstract excerpt

OBJECTIVE: The aim of the current study was to investigate whether Smad2 overexpression in JE cells induced alveolar bone loss, and to understand the mechanisms regulating the bone loss. METHODS: A mouse line was created that used a cytokeratin 14 (K14) promoter to overexpress Smad2 in the epithelium of the transgenic mice (K14-Smad2). Micro CT radiographs (μCT) were used to assess bone loss, bone volume, and...

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Identifiers

PMID: 27421098
DOI: 10.1016/j.archoralbio.2016.06.023

Genes

TNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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