Article
A new mechanism of antibiotic resistance in Enterobacteriaceae induced by a structural modification of the major porin.
Molecular microbiology - 1 Jul 2001
Dé E, Baslé A, Jaquinod M, Saint N, Malléa M, Molle G, Pagès J M
Abstract excerpt
In Enterobacter aerogenes, multidrug resistance involves a decrease in outer membrane permeability associated with changes in an as yet uncharacterized porin. We purified the major porin from the wild-type strain and a resistant strain. We characterized this porin, which was found to be an OmpC/OmpF-like protein and analysed its pore-forming properties in lipid bilayers. The porin from the resistant strain was...
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