Article
Altered antibiotic transport in OmpC mutants isolated from a series of clinical strains of multi-drug resistant E. coli.
PloS one - 1 Jan 2011
Lou Hubing, Chen Min, Black Susan S, Bushell Simon R, Ceccarelli Matteo, Mach Tivadar, Beis Konstantinos, Low Alison S, Bamford Victoria A, Booth Ian R, Bayley Hagan, Naismith James H
Abstract excerpt
Antibiotic-resistant bacteria, particularly gram negative species, present significant health care challenges. The permeation of antibiotics through the outer membrane is largely effected by the porin superfamily, changes in which contribute to antibiotic resistance. A series of antibiotic resistant E. coli isolates were obtained from a patient during serial treatment with various antibiotics. The sequence of...
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