Article
Molecular Basis of Filtering Carbapenems by Porins from β-Lactam-resistant Clinical Strains of Escherichia coli.
The Journal of biological chemistry - 5 Feb 2016
Bajaj Harsha, Scorciapino Mariano A, Moynié Lucile, Page Malcolm G P, Naismith James H, Ceccarelli Matteo, Winterhalter Mathias
Abstract excerpt
Integral membrane proteins known as porins are the major pathway by which hydrophilic antibiotics cross the outer membrane of Gram-negative bacteria. Single point mutations in porins can decrease the permeability of an antibiotic, either by reduction of channel size or modification of electrostatics in the channel, and thereby confer clinical resistance. Here, we investigate four mutant OmpC proteins from four...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.