Article
Resistance to imipenem, cefepime, and cefpirome associated with mutation in Omp36 osmoporin of Enterobacter aerogenes.
Biochemical and biophysical research communications - 7 May 2004
Thiolas Aurélie, Bornet Charléric, Davin-Régli Anne, Pagès Jean-Marie, Bollet Claude
Abstract excerpt
Enterobacter aerogenes develops increased multidrug resistance via a functional alteration of outer-membrane permeability associated with a decrease in porin function. We have sequenced the gene coding the major porin of Enterobacter aerogenes, omp36. The sequence shows a high similarity with the Klebsiella pneumoniae ompK36 gene and is closely related to the enterobacterial OmpC family. Sequence analysis of...
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