Article
CX(3)CR1 and vascular adhesion protein-1-dependent recruitment of CD16(+) monocytes across human liver sinusoidal endothelium.
Hepatology (Baltimore, Md.) - 1 Jun 2010
Aspinall Alexander I, Curbishley Stuart M, Lalor Patricia F, Weston Chris J, Blahova Miroslava, Liaskou Evaggelia, Adams Rebecca M, Holt Andrew P, Adams David H
Abstract excerpt
UNLABELLED: The liver contains macrophages and myeloid dendritic cells (mDCs) that are critical for the regulation of hepatic inflammation. Most hepatic macrophages and mDCs are derived from monocytes recruited from the blood through poorly understood interactions with hepatic sinusoidal endothelial cells (HSECs). Human CD16(+) monocytes are thought to contain the precursor populations for tissue macrophages and...
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