Article
Comparisons of mutants lacking the Golgi UDP-galactose or GDP-mannose transporters establish that phosphoglycans are important for promastigote but not amastigote virulence in Leishmania major.
Infection and immunity - 1 Sept 2007
Capul Althea A, Hickerson Suzanne, Barron Tamara, Turco Salvatore J, Beverley Stephen M
Abstract excerpt
Abundant surface Leishmania phosphoglycans (PGs) containing [Gal(beta1,4)Man(alpha1-PO(4))]-derived repeating units are important at several points in the infectious cycle of this protozoan parasite. PG synthesis requires transport of activated nucleotide-sugar precursors from the cytoplasm to the Golgi apparatus. Correspondingly, null mutants of the L. major GDP-mannose transporter LPG2 lack PGs and are severely...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.