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Article

Evidence that free GPI glycolipids are essential for growth of Leishmania mexicana.

The EMBO journal - 17 May 1999

Ilgoutz S C, Zawadzki J L, Ralton J E, McConville M J

Abstract excerpt

The cell surface of the parasitic protozoan Leishmania mexicana is coated by glycosylphosphatidylinositol (GPI)-anchored glycoproteins, a GPI-anchored lipophosphoglycan and a class of free GPI glycolipids. To investigate whether the anchor or free GPIs are required for parasite growth we cloned the L.mexicana gene for dolichol-phosphate-mannose synthase (DPMS) and attempted to create DPMS knockout mutants by...

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Source

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Identifiers

PMID: 10329621
DOI: 10.1093/emboj/18.10.2746
PMCID: PMC1171356

Genes

GPI

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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