Staging of the pathophysiologic responses of the primate microvasculature to Escherichia coli and endotoxin: Examination of the elements of the compensated response and their links to the corresponding uncompensated lethal variants

Abstract excerpt

OBJECTIVE: Review of primate studies of Escherichia coli sepsis and endotoxemia with a reexamination of the rationale for diagnosis and treatment of these multistage disorders. SETTING: Animal research and intensive care units in a university medical school. SUBJECTS: Cyanocephalus baboons (E. coli) and normal human subjects (endotoxin). INTERVENTIONS: Baboon studies: anti-tissue factor, protein C, endothelial...

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