Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

IGF-1 receptor activity in the Golgi of migratory cancer cells depends on adhesion-dependent phosphorylation of Tyr 1250 and Tyr 1251

26 May 2020

Abstract excerpt

promoted IGF-1R translocation to and signaling from the Golgi to support an aggressive cancer phenotype. This process distinguishes IGF-1R from IR signaling and could contribute to the poor clinical efficacy of antibodies that target IGF-1R on the cell surface.

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Glycosylation and Glycoproteins Research
Share to Growth Hormone and Insulin-like Growth Factors
Share to Metabolism, Diabetes, and Cancer

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 32457113
DOI: 10.1126/scisignal.aba3176

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 23 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 8 closest

IGF-1 receptor activity in the Golgi of migratory cancer cells depends on adhesion-dependent phosphorylation of Tyr 1250 and Tyr 1251PMID 32457113Read ↗

RACK1-mediated integration of adhesion and insulin-like growth factor I (IGF-I) signaling and cell migration are defective in cells expressing an IGF-I receptor mutated at tyrosines 1250 and 1251.Semantic proximity Read ↗

Cooperative regulation of the invasive and metastatic phenotypes by different domains of the type I insulin-like growth factor receptor beta subunit.Semantic proximity Read ↗

IGF1 Binding to Integrin αvβ3 Induces Direct Gα13 Binding to IGF1R Kinase.Semantic proximity Read ↗

Targeting the IGF1 axis in cancer proliferationSemantic proximity Read ↗

IGF1-R signals through the RON receptor to mediate pancreatic cancer cell migrationSemantic proximity Read ↗

Dance of The Golgi: Understanding Golgi Dynamics in Cancer MetastasisSemantic proximity Read ↗

Drugging IGF-1R in cancer: New insights and emerging opportunitiesSemantic proximity Read ↗

Molecular aspects of tumor cell migration and invasion.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.