Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

LKB1 Associates with Brg1 and Is Necessary for Brg1-induced Growth Arrest

1 Aug 2001

Abstract excerpt

Inactivating mutations in the serine-threonine kinase LKB1 (STK11) are found in most patients with Peutz-Jeghers syndrome; however the function of LKB1 is unknown. We found that LKB1 binds to and regulates brahma-related gene 1 (Brg1), an essential component of chromatin remodeling complexes. The association requires the N terminus of LKB1 and the helicase domain of Brg1 and LKB1 stimulates the ATPase activity of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chromatin Remodeling and Cancer
Share to Genetic factors in colorectal cancer
Share to Genomics and Chromatin Dynamics

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 11445556
DOI: 10.1074/jbc.c100207200

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

LKB1 Associates with Brg1 and Is Necessary for Brg1-induced Growth ArrestPMID 11445556Read ↗

Growth suppression by Lkb1 is mediated by a G(1) cell cycle arrest.Semantic proximity Read ↗

Targeting the LKB1 tumor suppressor.Semantic proximity Read ↗

LKB1, a protein kinase regulating cell proliferation and polaritySemantic proximity Read ↗

The molecular mechanisms that underlie the tumor suppressor function of LKB1.Semantic proximity Read ↗

LKB1 preserves genome integrity by stimulating BRCA1 expression.Semantic proximity Read ↗

The role of STK11/LKB1 in cancer biology: implications for ovarian tumorigenesis and progressionSemantic proximity Read ↗

LKB1 Controls Human Bronchial Epithelial Morphogenesis through p114RhoGEF-Dependent RhoA ActivationSemantic proximity Read ↗

Insights into targeting LKB1 in tumorigenesisSemantic proximity Read ↗

Liver kinase B1 (LKB1) in the pathogenesis of epithelial cancers.Semantic proximity Read ↗

BRG1 and LKB1: tales of two tumor suppressor genes on chromosome 19p and lung cancerSemantic proximity Read ↗

LKB1-dependent signaling pathways.Semantic proximity Read ↗

LKB1 tumor suppressor protein regulates actin filament assembly through Rho and its exchange factor Dbl independently of kinase activity.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.