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Article

N- and C-terminal hydrophobic patches are involved in fibrillation of glucagon.

Biochemistry - 5 Dec 2006

Pedersen Jesper Søndergaard, Dikov Dancho, Otzen Daniel Erik

Abstract excerpt

Recent work suggests that the molecular structure of amyloid-like fibrils is determined by environmental conditions as well as amino acid sequence. To probe the involvement of side chains in fibrillation of the 29-residue hormone glucagon, we have measured fibrillation kinetics of 15 alanine mutants. At acidic pH, all of the mutants are able to form fibrils. However, substitution of hydrophobic residues in the N-...

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PMID: 17128989
DOI: 10.1021/bi061228n

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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