Article
N- and C-terminal hydrophobic patches are involved in fibrillation of glucagon.
Biochemistry - 5 Dec 2006
Pedersen Jesper Søndergaard, Dikov Dancho, Otzen Daniel Erik
Abstract excerpt
Recent work suggests that the molecular structure of amyloid-like fibrils is determined by environmental conditions as well as amino acid sequence. To probe the involvement of side chains in fibrillation of the 29-residue hormone glucagon, we have measured fibrillation kinetics of 15 alanine muta...
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