Article
A specific point mutant at position 1 of the influenza hemagglutinin fusion peptide displays a hemifusion phenotype.
Molecular biology of the cell - 1 Aug 1999
Qiao H, Armstrong R T, Melikyan G B, Cohen F S, White J M
Abstract excerpt
We showed previously that substitution of the first residue of the influenza hemagglutinin (HA) fusion peptide Gly1 with Glu abolishes fusion activity. In the present study we asked whether this striking phenotype was due to the charge or side-chain volume of the substituted Glu. To do this we generated and characterized six mutants with substitutions at position 1: Gly1 to Ala, Ser, Val, Glu, Gln, or Lys. We...
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