Article
Role of the Glu residues of the influenza hemagglutinin fusion peptide in the pH dependence of fusion activity.
Virology - 25 Oct 2001
Korte T, Epand R F, Epand R M, Blumenthal R
Abstract excerpt
To elucidate the role of the fusion peptide in influenza hemagglutinin (HA)-mediated fusion, we compared pH-dependent conformational changes and fusion mediated by wild-type and a mutant HA in which Glu residues at positions 11 and 15 of the fusion peptide are substituted for valine. The pH dependence of conformational changes and kinetics of fusion with erythrocytes was the same for both forms of HA. The time...
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