Article
Early uterine serous carcinoma: clonal origin of extrauterine disease.
International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists - 1 Jul 2001
Baergen R N, Warren C D, Isacson C, Ellenson L H
Abstract excerpt
Uterine serous carcinoma (USC) is an uncommon but aggressive type of endometrial carcinoma that is frequently associated with extrauterine disease despite minimal or no myometrial invasion. The origin of the extrauterine tumors in this setting remains controversial. The majority of USCs (90%) and endometrial intraepithelial carcinomas (78%), the putative precursor of USC, have p53 mutations, suggesting that p53...
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