Article
Association of leptin receptor polymorphism with insulin resistance.
European journal of endocrinology - 1 May 2004
Chiu Ken C, Chu Audrey, Chuang Lee-Ming, Saad Mohammed F
Abstract excerpt
OBJECTIVE: Although the role of the leptin receptor (LEPR) in obesity is well recognized, its role in insulin sensitivity remains unknown. DESIGN: This was a cross-sectional study to investigate the impact of the Q223R polymorphism of the LEPR gene on insulin sensitivity. METHODS: Sixty-seven glucose-tolerant Caucasians were enrolled. The insulin sensitivity index and glucose clearance were measured using a...
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